NP_004958.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
35,148 Da
NCBI Official Full Name
bone sialoprotein 2
NCBI Official Synonym Full Names
integrin-binding sialoprotein
NCBI Protein Information
bone sialoprotein 2; BSP II; bone sialoprotein II; cell-binding sialoprotein
UniProt Protein Name
Bone sialoprotein 2
UniProt Synonym Protein Names
Bone sialoprotein II; BSP II; Cell-binding sialoprotein; Integrin-binding sialoprotein
UniProt Synonym Gene Names
UniProt Entry Name
SIAL_HUMAN
NCBI Summary for BSP
The protein encoded by this gene is a major structural protein of the bone matrix. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor. [provided by RefSeq, Jul 2008]
UniProt Comments for BSP
Sialoprotein-2: Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment.
Protein type: Secreted; Motility/polarity/chemotaxis; Cell adhesion; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 4q21.1
Cellular Component: extracellular space; membrane; extracellular region
Biological Process: osteoblast differentiation; extracellular matrix organization and biogenesis; biomineral formation; cell adhesion
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Products associated with BSP elisa kit
Pathways associated with BSP elisa kit
Diseases associated with BSP elisa kit
Organs/Tissues associated with BSP elisa kit
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