NP_037219.1
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NCBI GenBank Nucleotide #
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UniProt Related Accession #
Molecular Weight
25,889 Da
NCBI Official Full Name
CD81 antigen
NCBI Official Synonym Full Names
Cd81 molecule
NCBI Official Synonym Symbols
NCBI Protein Information
CD81 antigen; CD 81 antigen; 26 kDa cell surface protein TAPA-1; target of the antiproliferative antibody 1; CD81 antigen (target of antiproliferative antibody 1)
UniProt Protein Name
CD81 antigen
UniProt Synonym Protein Names
26 kDa cell surface protein TAPA-1; Target of the antiproliferative antibody 1; CD_antigen: CD81
UniProt Synonym Gene Names
UniProt Entry Name
CD81_RAT
NCBI Summary for CD81
may play a role in glial scar formation in response to astrocyte injury; may be involved in regulation of cell interactions and cell growth [RGD, Feb 2006]
UniProt Comments for CD81
CD81: May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May act as the viral receptor for HCV. Defects in CD81 are the cause of immunodeficiency common variable type 6 (CVID6); also called antibody deficiency due to CD81 defect. CVID6 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. Belongs to the tetraspanin (TM4SF) family.
Protein type: Membrane protein, integral; Cell cycle regulation; Membrane protein, multi-pass
Cellular Component: focal adhesion; membrane; integral to plasma membrane; apical plasma membrane; integral to membrane; immunological synapse; vesicle
Molecular Function: protein binding
Biological Process: protein localization; positive regulation of peptidyl-tyrosine phosphorylation; activation of MAPK activity; regulation of growth; positive regulation of 1-phosphatidylinositol 4-kinase activity; positive regulation of cell proliferation; response to wounding; positive regulation of B cell proliferation; phosphatidylinositol biosynthetic process; phosphatidylinositol metabolic process; regulation of cell proliferation
Research Articles on CD81
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Products associated with CD81 elisa kit
Pathways associated with CD81 elisa kit
Diseases associated with CD81 elisa kit
Organs/Tissues associated with CD81 elisa kit
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