AAB58249.1
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UniProt Secondary Accession #
Molecular Weight
43,009 Da
NCBI Official Full Name
differentially repressed by testosterone and dihydrotestosterone
UniProt Protein Name
Protein NDRG1
UniProt Synonym Protein Names
N-myc downstream-regulated gene 1 protein; Protein Ndr1
UniProt Synonym Gene Names
UniProt Entry Name
NDRG1_MOUSE
UniProt Comments for DHT
NDRG1: a hypoxia-inducible anti-apoptotic protein. Promotes proliferation and correlates with invasion, metastasis and poor prognosis in many cancers. Is involved in growth arrest and cell differentiation during development. A ubiquitous Rab4a effector protein that modulates angiogenesis and is involved in vesicular recycling of E-cadherin. Colocalizes with transferrin during the recycling in cells. NDRG1 knockdown delays the recycling rate of transferrin, while its overexpression increases the rate of transferrin recycling. Interacts with SIRT1/p53 signaling to attenuate hypoxic injury in human trophoblasts. Its expression is induced by an elevation of free intracellular calcium ion caused by nickel ion exposure. Highly expressed in placental membranes, prostate, kidney, small intestine, ovary, peripheral nerves and Schwann cells. Defects in NDRG1 are the cause of Charcot-Marie-Tooth disease type 4D (CMT4D).
Protein type: Vesicle; Cell development/differentiation
Cellular Component: microtubule cytoskeleton; centrosome; microtubule; cytoskeleton; cell-cell adherens junction; membrane; recycling endosome membrane; perinuclear region of cytoplasm; cytoplasm; plasma membrane; nucleus; myelin sheath
Molecular Function: gamma-tubulin binding; cadherin binding; microtubule binding; Rab GTPase binding
Biological Process: myelin maintenance in the peripheral nervous system; mast cell activation
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