NP_082627.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
31,454 Da
NCBI Official Full Name
R-spondin-3
NCBI Official Synonym Full Names
R-spondin 3 homolog (Xenopus laevis)
NCBI Official Synonym Symbols
Thsd2; AW742308; Cristin1; 2810459H04Rik [Similar Products]
NCBI Protein Information
R-spondin-3; cabriolet; cristin 1; cristin-1; nucleopondin; roof plate-specific spondin-3; thrombospondin, type I, domain 2; cysteine-rich and single thrombospondin domain-containing protein 1
UniProt Protein Name
R-spondin-3
UniProt Synonym Protein Names
Cabriolet; Cysteine-rich and single thrombospondin domain-containing protein 1; Cristin-1; Nucleopondin; Roof plate-specific spondin-3
UniProt Synonym Gene Names
UniProt Entry Name
RSPO3_MOUSE
UniProt Comments for RSPO3
R-spondin-3: Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Belongs to the R-spondin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted, signal peptide; Cell development/differentiation; Secreted
Cellular Component: extracellular space; extracellular region
Molecular Function: heparin binding; frizzled binding; receptor binding
Biological Process: Wnt receptor signaling pathway; response to stimulus; angiogenesis
Research Articles on RSPO3
Precautions
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Disclaimer
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Diseases associated with RSPO3 elisa kit
Organs/Tissues associated with RSPO3 elisa kit
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