NP_031914.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
78,861 Da
NCBI Official Full Name
segment polarity protein dishevelled homolog DVL-2
NCBI Official Synonym Full Names
dishevelled 2, dsh homolog (Drosophila)
NCBI Protein Information
segment polarity protein dishevelled homolog DVL-2; DSH homolog 2; dishevelled-2
UniProt Protein Name
Segment polarity protein dishevelled homolog DVL-2
UniProt Synonym Protein Names
DSH homolog 2
UniProt Synonym Gene Names
UniProt Entry Name
DVL2_MOUSE
UniProt Comments for DVL2
DVL2: a protein in the WNT/planar cell polarity (PCP) signaling pathway. Dvl2-deficient mice indicate that Dvl2 is essential for normal cardiac morphogenesis, somite segmentation and neural tube closure. Transduces the Wnt signal by interacting with the cytoplasmic Axin complex. Dvl and Axin each contain a DIX domains, which mediate their dynamic polymerization. The Dvl-Axin interaction is essential for Wnt signaling. Interacts through its PDZ domain with the C-terminal regions of VANGL1 and VANGL2. Interacts with Dixin and Rac. There is functional redundancy between Dvl1 and Dvl2 in some phenotypes.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Cellular Component: cytoskeleton; membrane; clathrin-coated vesicle; apical part of cell; cytoplasm; plasma membrane; cell cortex; cytoplasmic vesicle; cytosol; nucleus
Molecular Function: protein domain specific binding; identical protein binding; protein binding; protein self-association; frizzled binding
Biological Process: heart morphogenesis; transcription from RNA polymerase II promoter; positive regulation of JNK activity; Wnt receptor signaling pathway; convergent extension involved in neural plate elongation; Wnt receptor signaling pathway, planar cell polarity pathway; heart development; multicellular organismal development; positive regulation of transcription, DNA-dependent; segmentation; Wnt receptor signaling pathway through beta-catenin; segment specification; convergent extension involved in organogenesis; neural tube closure; positive regulation of transcription factor activity; positive regulation of protein amino acid phosphorylation
Research Articles on DVL2
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Pathways associated with DVL2 elisa kit
Diseases associated with DVL2 elisa kit
Organs/Tissues associated with DVL2 elisa kit
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