NP_001157740.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
337,000 Da
NCBI Official Full Name
kalirin isoform 2
NCBI Official Synonym Full Names
kalirin, RhoGEF kinase
NCBI Official Synonym Symbols
DUET; TRAD; Gm539; Hapip; AV235988; 2210407G14Rik; E530005C20Rik [Similar Products]
NCBI Protein Information
kalirin; protein Duo; huntingtin-associated protein interacting protein (duo); serine/threonine kinase with Dbl- and pleckstrin homology domain; serine/threonine kinase with Dbl- and pleckstrin homology domains; serine/threonine-protein kinase with Dbl- and pleckstrin homology domain
UniProt Protein Name
Kalirin
UniProt Synonym Protein Names
Protein Duo; Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain
UniProt Entry Name
KALRN_MOUSE
UniProt Comments for KALRN
kalirin: a bifunctional enzyme with protein kinase activity and guanine-exchange factor (GEF) activity. A protein kinase of the CAMK group. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity. Genetic variants are associated with susceptibility to coronary heart disease type 5 (CHDS5), a multifactorial disease characterized by an imbalance between myocardial functional requirements and the capacity of the coronary vessels to supply sufficient blood flow. Interacts with the C-terminal of peptidylglycine alpha-amidating monooxygenase (PAM) and with the huntingtin-associated protein 1 (HAP1) Interacts with FASLG. The two GEF domains catalyze nucleotide exchange for RAC1 and RhoA which are bound by DH1 and DH2 respectively. The two GEF domains appear to play differing roles in neuronal development and axonal outgrowth. SH3 1 binds to the first GEF domain inhibiting GEF activity only when in the presence of a PXXP peptide, suggesting that the SH3 domain/peptide interaction mediates binding to GEF1. CRK1 SH3 domain binds to and inhibits GEF1 activity. 6 isoforms of the human protein are produced by alternative splicing. Isoform 2 is brain specific and is highly expressed in cerebral cortex, putamen, amygdala, hippocampus and caudate nucleus. Weakly expressed in brain stem and cerebellum. Isoform 4 is expressed in skeletal muscle.
Protein type: Protein kinase, CAMK; GEFs, Rac/Rho; GEFs; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Kinase, protein; CAMK group; Trio family
Cellular Component: neuron projection; cytoskeleton; cell soma; perinuclear region of cytoplasm; cytoplasm
Molecular Function: transferase activity; protein serine/threonine kinase activity; Rho guanyl-nucleotide exchange factor activity; enzyme binding; metal ion binding; guanyl-nucleotide exchange factor activity; transferase activity, transferring phosphorus-containing groups; nucleotide binding; kinase activity; ATP binding; protein kinase activity
Biological Process: nervous system development; axonogenesis; regulation of dendrite development; regulation of Rho protein signal transduction; protein amino acid phosphorylation; phosphorylation; positive regulation of GTPase activity
Research Articles on KALRN
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Pathways associated with KALRN elisa kit
Diseases associated with KALRN elisa kit
Organs/Tissues associated with KALRN elisa kit
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