NP_001020416.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
27,168 Da
NCBI Official Full Name
Golli-Mbp isoform 2
NCBI Official Synonym Full Names
myelin basic protein
NCBI Official Synonym Symbols
mld; shi; Hmbpr; C76307; R75289; golli-mbp [Similar Products]
NCBI Protein Information
Golli-Mbp; myelin basic protein; shiverer; myelin deficient; myelin A1 protein
UniProt Protein Name
Myelin basic protein
UniProt Synonym Protein Names
Myelin A1 protein
UniProt Synonym Gene Names
UniProt Entry Name
MBP_MOUSE
NCBI Summary for MBP
The protein encoded by the classic Mbp gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, Mbp-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long Mbp gene (otherwise called "Golli-Mbp") that contains 3 additional exons located upstream of the classic Mbp exons. Alternative splicing from the Golli and the Mbp transcription start sites gives rise to 2 sets of Mbp-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-Mbp, spliced in-frame to 1 or more Mbp exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to Mbp aa sequence. The second family of transcripts contain only Mbp exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the Mbp transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. Mutation of the Mbp gene is associated with the 'shiverer' and 'myelin deficient' phenotypes in mouse. [provided by RefSeq, Jul 2008]
UniProt Comments for MBP
Function: The classic group of MBP isoforms (isoform 4-isoform 13) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined to optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function.1 PublicationManual assertion based on experiment in:Ref.17
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Products associated with MBP elisa kit
Pathways associated with MBP elisa kit
Diseases associated with MBP elisa kit
Organs/Tissues associated with MBP elisa kit
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