NP_057887.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
106,082 Da
NCBI Official Full Name
reversion-inducing cysteine-rich protein with Kazal motifs
NCBI Official Synonym Full Names
reversion-inducing-cysteine-rich protein with kazal motifs
NCBI Official Synonym Symbols
NCBI Protein Information
reversion-inducing cysteine-rich protein with Kazal motifs; suppression of tumorigenicity 15; membrane-anchored glycoprotein RECK; Reversion-inducing cysteine-rich protein with Kazal motifs precursor (mRECK)
UniProt Protein Name
Reversion-inducing cysteine-rich protein with Kazal motifs
UniProt Synonym Gene Names
UniProt Entry Name
RECK_MOUSE
UniProt Comments for RECK
RECK: Negatively regulates matrix metalloproteinase-9 (MMP-9) by suppressing MMP-9 secretion and by direct inhibition of its enzymatic activity. RECK down-regulation by oncogenic signals may facilitate tumor invasion and metastasis. Appears to also regulate MMP-2 and MT1-MMP, which are involved in cancer progression. Interacts with MMP-9. Expressed in various tissues and untransformed cells. It is undetectable in tumor-derived cell lines and oncogenically transformed cells.
Protein type: Membrane protein, GPI anchor; Tumor suppressor
Cellular Component: membrane; plasma membrane
Molecular Function: serine-type endopeptidase inhibitor activity; protease inhibitor activity; endopeptidase inhibitor activity
Biological Process: extracellular matrix organization and biogenesis; negative regulation of peptidase activity; blood vessel maturation; positive regulation of Notch signaling pathway; embryo implantation
Research Articles on RECK
Precautions
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Disclaimer
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Diseases associated with RECK elisa kit
Organs/Tissues associated with RECK elisa kit
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