AAA52054.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
11,954 Da
NCBI Official Full Name
colipase
NCBI Official Synonym Full Names
colipase, pancreatic
NCBI Protein Information
colipase; pancreatic colipase preproprotein
UniProt Protein Name
Colipase
UniProt Entry Name
COL_HUMAN
NCBI Summary for CLPS
The protein encoded by this gene is a cofactor needed by pancreatic lipase for efficient dietary lipid hydrolysis. It binds to the C-terminal, non-catalytic domain of lipase, thereby stabilizing an active conformation and considerably increasing the overall hydrophobic binding site. The gene product allows lipase to anchor noncovalently to the surface of lipid micelles, counteracting the destabilizing influence of intestinal bile salts. This cofactor is only expressed in pancreatic acinar cells, suggesting regulation of expression by tissue-specific elements. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
UniProt Comments for CLPS
CLPS: Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase. Belongs to the colipase family.
Protein type: Secreted, signal peptide; Activator; Secreted
Chromosomal Location of Human Ortholog: 6p21.31
Cellular Component: extracellular region
Molecular Function: enzyme activator activity
Biological Process: positive regulation of catalytic activity; phototransduction, visible light; lipid metabolic process; retinoid metabolic process; lipid catabolic process; lipid digestion
Research Articles on CLPS
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Products associated with CLPS elisa kit
Pathways associated with CLPS elisa kit
Diseases associated with CLPS elisa kit
Organs/Tissues associated with CLPS elisa kit
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