NP_002997.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
44,648 Da
NCBI Official Full Name
P-selectin glycoprotein ligand 1 isoform 2
NCBI Official Synonym Full Names
selectin P ligand
NCBI Protein Information
P-selectin glycoprotein ligand 1; cutaneous lymphocyte-associated associated antigen
UniProt Protein Name
P-selectin glycoprotein ligand 1
UniProt Synonym Protein Names
Selectin P ligand; CD_antigen: CD162
UniProt Synonym Gene Names
UniProt Entry Name
SELPL_HUMAN
NCBI Summary for PSGL-1
This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011]
UniProt Comments for PSGL-1
SELPLG: A SLe(x)-type glycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. PSGL1 is critical for the initial leukocyte capture.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 12q24
Cellular Component: membrane; integral to plasma membrane; integral to membrane; plasma membrane
Molecular Function: protein binding; receptor binding
Biological Process: blood coagulation; cell adhesion; leukocyte tethering or rolling; leukocyte adhesive activation; leukocyte migration
Research Articles on PSGL-1
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Products associated with PSGL-1 elisa kit
Pathways associated with PSGL-1 elisa kit
Diseases associated with PSGL-1 elisa kit
Organs/Tissues associated with PSGL-1 elisa kit
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