NP_001130012.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
42,158 Da
NCBI Official Full Name
apolipoprotein L1 isoform a
NCBI Official Synonym Full Names
apolipoprotein L, 1
NCBI Protein Information
apolipoprotein L1
UniProt Protein Name
Apolipoprotein L1
UniProt Synonym Protein Names
Apolipoprotein L; Apo-L; ApoL; Apolipoprotein L-I; ApoL-I
UniProt Synonym Gene Names
UniProt Entry Name
APOL1_HUMAN
NCBI Summary for APOL1
This gene encodes a secreted high density lipoprotein which binds to apolipoprotein A-I. Apolipoprotein A-I is a relatively abundant plasma protein and is the major apoprotein of HDL. It is involved in the formation of most cholesteryl esters in plasma and also promotes efflux of cholesterol from cells. This apolipoprotein L family member may play a role in lipid exchange and transport throughout the body, as well as in reverse cholesterol transport from peripheral cells to the liver. Several different transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]
UniProt Comments for APOL1
APOL1: May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver. Defects in APOL1 are the cause of focal segmental glomerulosclerosis type 4 (FSGS4). It is a renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and edema. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation. Belongs to the apolipoprotein L family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Channel, chloride; Secreted; Lipid-binding; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 22q13.1
Cellular Component: extracellular space; extracellular region; intrinsic to membrane
Molecular Function: chloride channel activity; protein binding; lipid binding
Biological Process: receptor-mediated endocytosis; cholesterol metabolic process; killing of cells of another organism; cytolysis; innate immune response; lipoprotein metabolic process; chloride transport; lipid transport
Disease: Focal Segmental Glomerulosclerosis 4, Susceptibility To
Research Articles on APOL1
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Products associated with APOL1 elisa kit
Pathways associated with APOL1 elisa kit
Diseases associated with APOL1 elisa kit
Organs/Tissues associated with APOL1 elisa kit
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