AAI04971.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
34,211 Da
NCBI Official Full Name
Engrailed homeobox 2
NCBI Official Synonym Full Names
engrailed homeobox 2
NCBI Protein Information
homeobox protein engrailed-2; hu-En-2; engrailed homolog 2; homeobox protein en-2
UniProt Protein Name
Homeobox protein engrailed-2
UniProt Synonym Gene Names
UniProt Entry Name
HME2_HUMAN
NCBI Summary for EN2
Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system. [provided by RefSeq, Jul 2008]
UniProt Comments for EN2
En-2: Genetic variations in EN2 may be associated with susceptibility to autism. Belongs to the engrailed homeobox family.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 7q36
Cellular Component: membrane; nucleus
Molecular Function: sequence-specific DNA binding
Biological Process: multicellular organismal development; midbrain development; neuron development; positive regulation of transcription from RNA polymerase II promoter; hindbrain development
Disease: Autism, Susceptibility To, 10
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Products associated with EN2 elisa kit
Diseases associated with EN2 elisa kit
Organs/Tissues associated with EN2 elisa kit
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