AAB38570.1
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UniProt Secondary Accession #
Molecular Weight
46,403 Da
NCBI Official Full Name
shh, partial
UniProt Protein Name
Sonic hedgehog protein A
UniProt Synonym Protein Names
VHH-1Cleaved into the following 2 chains:Sonic hedgehog protein A N-product; Sonic hedgehog protein A C-product
UniProt Synonym Gene Names
UniProt Entry Name
SHH_DANRE
UniProt Comments for SHH
Intercellular signal essential for a variety of patterning events during development. Signal produced by the notochord that induces somite patterning, dorso-ventral patterning of the brain and early patterning of the developing eyes. Displays floor plate-inducing activity. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO ().
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