Q4G0N8.2
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
135,206 Da
NCBI Official Full Name
Sodium/hydrogen exchanger 10
NCBI Official Synonym Full Names
solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1
NCBI Protein Information
sodium/hydrogen exchanger 10; sNHE; NHE-10; Na(+)/H(+) exchanger 10; solute carrier family 9 member C1; solute carrier family 10 member 10; solute carrier family 9, member 10; solute carrier family 9, isoform 10; sperm-specific Na(+)/H(+) exchanger; sperm-specific sodium proton exchanger
UniProt Protein Name
Sodium/hydrogen exchanger 10
UniProt Synonym Protein Names
Na(+)/H(+) exchanger 10; NHE-10; Solute carrier family 9 member 10; Solute carrier family 9 member C1; Sperm-specific Na(+)/H(+) exchanger
UniProt Synonym Gene Names
UniProt Entry Name
SL9C1_HUMAN
NCBI Summary for SCD40L
SLC9A10 is a member of the sodium-hydrogen exchanger (NHE) family (see SLC9A1, MIM 107310) and is required for male fertility and sperm motility (Wang et al., 2003 [PubMed 14634667]).[supplied by OMIM, Apr 2009]
UniProt Comments for SCD40L
NHE10: Sperm-specific sodium/hydrogen exchanger involved in intracellular pH regulation of spermatozoa. Required for sperm motility and fertility. Involved in sperm cell hyperactivation, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for the expression and bicarbonate regulation of the soluble adenylyl cyclase (sAC). Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Transporter, ion channel; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 3q13.2
Cellular Component: plasma membrane; integral to membrane
Molecular Function: solute:hydrogen antiporter activity
Biological Process: sperm motility; multicellular organismal development; sodium ion transport; spermatogenesis; cell differentiation; transmembrane transport
Research Articles on SCD40L
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Products associated with SCD40L elisa kit
Pathways associated with SCD40L elisa kit
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