AAC60687.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
24,356 Da
NCBI Official Full Name
tissue inhibitor of metalloproteinase type 2
NCBI Official Synonym Full Names
TIMP metallopeptidase inhibitor 2
NCBI Protein Information
metalloproteinase inhibitor 2; TIMP-2; tissue inhibitor of metalloproteinase 2; tissue inhibitor of metalloproteinases 2
UniProt Protein Name
Metalloproteinase inhibitor 2
UniProt Synonym Protein Names
Tissue inhibitor of metalloproteinases 2; TIMP-2
UniProt Synonym Gene Names
UniProt Entry Name
TIMP2_RAT
NCBI Summary for TIMP-2
acts as an inhibitor of metallopeptidase activity; may play a role in tissue remodeling during spermatogenesis [RGD, Feb 2006]
UniProt Comments for TIMP-2
TIMP2: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19. Interacts (via the C-terminal) with MMP2 (via the C- terminal PEX domain); the interaction inhibits the MMP2 activity. Down-regulated by TGFB1. Belongs to the protease inhibitor I35 (TIMP) family.
Protein type: Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted; Extracellular matrix; Inhibitor; Cell development/differentiation
Cellular Component: extracellular space; proteinaceous extracellular matrix; neuron projection; growth cone; cell surface; cell soma; basement membrane; nucleus
Molecular Function: integrin binding; metalloendopeptidase inhibitor activity; protease binding; metal ion binding; enzyme activator activity
Biological Process: response to drug; negative regulation of proteolysis; positive regulation of catalytic activity; regulation of Rap protein signal transduction; negative regulation of metalloenzyme activity; central nervous system development; regulation of neuron differentiation; regulation of cAMP metabolic process; response to hormone stimulus; negative regulation of membrane protein ectodomain proteolysis; negative regulation of cell proliferation; positive regulation of MAPKKK cascade; response to cytokine stimulus; regulation of MAPKKK cascade; negative regulation of Ras protein signal transduction; spermatogenesis; negative regulation of mitotic cell cycle; positive regulation of adenylate cyclase activity; positive regulation of neuron differentiation; aging
Research Articles on TIMP-2
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Products associated with TIMP-2 elisa kit
Pathways associated with TIMP-2 elisa kit
Diseases associated with TIMP-2 elisa kit
Organs/Tissues associated with TIMP-2 elisa kit
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