NP_001008767.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
44,018 Da
NCBI Official Full Name
thioredoxin-interacting protein
NCBI Official Synonym Full Names
thioredoxin interacting protein
NCBI Official Synonym Symbols
NCBI Protein Information
thioredoxin-interacting protein; vitamin D3 up-regulated protein 1; upregulated by 1,25-dihydroxyvitamin D-3
UniProt Protein Name
Thioredoxin-interacting protein
UniProt Synonym Protein Names
Vitamin D3 up-regulated protein 1
UniProt Synonym Gene Names
UniProt Entry Name
TXNIP_RAT
NCBI Summary for TXNIP
regulates thioredoxin to play an important role in the preservation of cellular viability [RGD, Feb 2006]
UniProt Comments for TXNIP
TXNIP: May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over- expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Belongs to the arrestin family.
Protein type: Motility/polarity/chemotaxis; Tumor suppressor; Mitochondrial; Apoptosis
Cellular Component: cell; cytoplasm; mitochondrial intermembrane space; intracellular; nucleus
Molecular Function: enzyme inhibitor activity; ubiquitin protein ligase binding
Biological Process: response to drug; transcription, DNA-dependent; positive regulation of apoptosis; platelet-derived growth factor receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; negative regulation of cell division; response to estradiol stimulus; regulation of cell proliferation; keratinocyte differentiation; response to hydrogen peroxide; response to mechanical stimulus; protein import into nucleus; negative regulation of catalytic activity; response to glucose stimulus; response to oxidative stress; response to progesterone stimulus; response to calcium ion
Research Articles on TXNIP
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Diseases associated with TXNIP elisa kit
Organs/Tissues associated with TXNIP elisa kit
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