KFZ59633.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
Molecular Weight
85,360 Da
NCBI Official Full Name
6-phosphofructokinase, liver type, partial
UniProt Protein Name
ATP-dependent 6-phosphofructokinase, liver type
UniProt Synonym Protein Names
6-phosphofructokinase type B; Phosphofructo-1-kinase isozyme B; PFK-B; Phosphohexokinase
UniProt Synonym Gene Names
UniProt Entry Name
PFKAL_MOUSE
UniProt Comments for PFKL
PFKL: phosphofructokinase, liver type. An ubiquitous metabolic enzyme involved in the synthesis and degradation of fructose 2,6-bisphosphate. Key control step of glycolysis. An allosteric enzyme activated by ADP, AMP, or fructose bisphosphate and inhibited by ATP or citrate. Activity: ATP D-fructose 6-phosphate = ADP D-fructose 1,6-bisphosphate. The holoenzyme consists of 4 subunits. The liver and muscle enzymes are homo-tetramers of four liver or muscle isoforms, respectively. The red blood cell enzyme consists hetero-tetramers of the muscle and liver isoforms. A subunit composition with a higher proportion of platelet type subunits is found in platelets, brain and fibroblasts. Two alternatively spliced isoforms have been described.
Protein type: EC 2.7.1.11; Carbohydrate Metabolism - pentose phosphate pathway; Carbohydrate Metabolism - galactose; Kinase, other; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - fructose and mannose
Cellular Component: 6-phosphofructokinase complex; membrane; cytoplasm; cytosol
Molecular Function: monosaccharide binding; transferase activity; identical protein binding; metal ion binding; nucleotide binding; kinase activity; kinase binding; catalytic activity; 6-phosphofructokinase activity; ATP binding
Biological Process: fructose 1,6-bisphosphate metabolic process; glycolysis; metabolic process; carbohydrate phosphorylation; carbohydrate metabolic process; response to glucose stimulus; fructose 6-phosphate metabolic process; phosphorylation; protein oligomerization; protein homotetramerization; negative regulation of insulin secretion
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Diseases associated with PFKL elisa kit
Organs/Tissues associated with PFKL elisa kit
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