NP_036433.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
157,236 Da
NCBI Official Full Name
membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform 1
NCBI Official Synonym Full Names
membrane associated guanylate kinase, WW and PDZ domain containing 2
NCBI Official Synonym Symbols
AIP1; AIP-1; ARIP1; SSCAM; MAGI-2; ACVRIP1 [Similar Products]
NCBI Protein Information
membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
UniProt Protein Name
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
UniProt Synonym Protein Names
Atrophin-1-interacting protein 1; AIP-1; Atrophin-1-interacting protein A; Membrane-associated guanylate kinase inverted 2; MAGI-2
UniProt Synonym Gene Names
UniProt Entry Name
MAGI2_HUMAN
NCBI Summary for MAGI2
The protein encoded by this gene interacts with atrophin-1. Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. This encoded protein is characterized by two WW domains, a guanylate kinase-like domain, and multiple PDZ domains. It has structural similarity to the membrane-associated guanylate kinase homologue (MAGUK) family. [provided by RefSeq, Jul 2008]
UniProt Comments for MAGI2
AIP1: a scaffold molecule at synaptic junctions that apparently couples neurotransmitter receptors and cell adhesion proteins. Contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. Contains two WW domains, a guanylate kinase-like domain, and multiple PDZ domains. It has structural similarity to the membrane-associated guanylate kinase homologue (MAGUK) family. This protein is brain specific, where it appears to be widely expressed in both neurons and glia. Enhances the ability of PTEN to suppress AKT1 activation. Two splice-variant isoforms have been described.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 7q21
Cellular Component: cytoplasm; dendrite; late endosome; nucleus; perinuclear region of cytoplasm; plasma membrane; postsynaptic density; protein complex; synapse; tight junction
Molecular Function: beta-1 adrenergic receptor binding; phosphatase binding; protein binding; receptor signaling complex scaffold activity; SMAD binding
Biological Process: negative regulation of activin receptor signaling pathway; negative regulation of cell migration; negative regulation of cell proliferation; negative regulation of protein kinase B signaling cascade; positive regulation of phosphoprotein phosphatase activity; positive regulation of receptor internalization; protein heterooligomerization; receptor clustering
Research Articles on MAGI2
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Products associated with MAGI2 blocking peptide
Pathways associated with MAGI2 blocking peptide
Diseases associated with MAGI2 blocking peptide
Organs/Tissues associated with MAGI2 blocking peptide
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