NP_003456.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
49,613 Da
NCBI Official Full Name
chitotriosidase-1 isoform 1
NCBI Official Synonym Full Names
chitinase 1
NCBI Protein Information
chitotriosidase-1
UniProt Protein Name
Chitotriosidase-1
UniProt Synonym Protein Names
Chitinase-1
UniProt Entry Name
CHIT1_HUMAN
NCBI Summary for CHIT1
Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens. Several alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jan 2012]
UniProt Comments for CHIT1
CHIT1: Degrades chitin, chitotriose and chitobiose. May participate in the defense against nematodes and other pathogens. Isoform 3 has no enzymatic activity. Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted, signal peptide; Carbohydrate Metabolism - amino sugar and nucleotide sugar; Hydrolase; EC 3.2.1.14; Secreted
Chromosomal Location of Human Ortholog: 1q32.1
Cellular Component: extracellular region; extracellular space; lysosome
Molecular Function: chitin binding; chitinase activity; endochitinase activity; hydrolase activity, hydrolyzing O-glycosyl compounds
Biological Process: carbohydrate metabolic process; chitin catabolic process; immune response; polysaccharide catabolic process; response to bacterium
Disease: Chitotriosidase Deficiency
Research Articles on CHIT1
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Pathways associated with CHIT1 blocking peptide
Diseases associated with CHIT1 blocking peptide
Organs/Tissues associated with CHIT1 blocking peptide
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