NP_001098547.3
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NCBI GenBank Nucleotide #
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UniProt Related Accession #
NCBI Official Full Name
MDS1 and EVI1 complex locus protein EVI1 isoform a
NCBI Official Synonym Full Names
MDS1 and EVI1 complex locus
NCBI Official Synonym Symbols
EVI1; MDS1; PRDM3; RUSAT2; MDS1-EVI1; AML1-EVI-1 [Similar Products]
NCBI Protein Information
MDS1 and EVI1 complex locus protein EVI1
UniProt Protein Name
MDS1 and EVI1 complex locus protein MDS1
UniProt Synonym Protein Names
Myelodysplasia syndrome 1 protein; Myelodysplasia syndrome-associated protein 1
UniProt Synonym Gene Names
NCBI Summary for MECOM
The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
UniProt Comments for MECOM
MDS1: A chromosomal aberration involving MDS1 is found in a form of acute myeloid leukemia (AML). Translocation t(3;21) with AML1. 6 isoforms of the human protein are produced by alternative promoter.
Protein type: Transcription factor
Chromosomal Location of Human Ortholog: 3q26.2
Cellular Component: cytoplasm; cytosol; Golgi apparatus; histone deacetylase complex; intracellular membrane-bound organelle; nuclear speck; nucleoplasm; nucleus
Molecular Function: DNA binding; histone-lysine N-methyltransferase activity; metal ion binding; protein binding; protein homodimerization activity; transcription factor activity
Biological Process: apoptosis; cell differentiation; negative regulation of JNK cascade; negative regulation of programmed cell death; negative regulation of transcription, DNA-dependent; negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of transcription, DNA-dependent; regulation of cell cycle; regulation of transcription, DNA-dependent; transcription, DNA-dependent
Research Articles on MECOM
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Pathways associated with MECOM blocking peptide
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