NP_689952.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
30,172 Da
NCBI Official Full Name
homeobox protein Hox-A9
NCBI Official Synonym Full Names
homeobox A9
NCBI Protein Information
homeobox protein Hox-A9
UniProt Protein Name
Homeobox protein Hox-A9
UniProt Synonym Protein Names
Homeobox protein Hox-1G
UniProt Synonym Gene Names
UniProt Entry Name
HXA9_HUMAN
NCBI Summary for HOXA9
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is highly similar to the abdominal-B (Abd-B) gene of Drosophila. A specific translocation event which causes a fusion between this gene and the NUP98 gene has been associated with myeloid leukemogenesis. Read-through transcription exists between this gene and the upstream homeobox A10 (HOXA10) gene.[provided by RefSeq, Mar 2011]
UniProt Comments for HOXA9
HOXA9: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation. A chromosomal aberration involving HOXA9 is found in a form of acute myeloid leukemia. Translocation t(7;11)(p15;p15) with NUP98. A chromosomal aberration involving HOXA9 may contribute to disease progression in chronic myeloid leukemia. Translocation t(7;17)(p15;q23) with MSI2. Belongs to the Abd-B homeobox family.
Protein type: Oncoprotein; DNA-binding
Chromosomal Location of Human Ortholog: 7p15.2
Cellular Component: cytoplasm; nucleus; transcription factor complex
Molecular Function: enzyme binding; protein binding; sequence-specific DNA binding
Biological Process: anterior/posterior pattern formation; embryonic forelimb morphogenesis; embryonic skeletal development; endothelial cell activation; male gonad development; mammary gland development; multicellular organismal development; negative regulation of myeloid cell differentiation; proximal/distal pattern formation; regulation of transcription, DNA-dependent; single fertilization; spermatogenesis; transcription, DNA-dependent; uterus development
Research Articles on HOXA9
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Products associated with HOXA9 blocking peptide
Pathways associated with HOXA9 blocking peptide
Diseases associated with HOXA9 blocking peptide
Organs/Tissues associated with HOXA9 blocking peptide
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