NP_001002914.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
29,875 Da
NCBI Official Full Name
BTB/POZ domain-containing protein KCTD11
NCBI Official Synonym Full Names
potassium channel tetramerization domain containing 11
NCBI Official Synonym Symbols
REN; KCASH1; C17orf36; REN/KCTD11 [Similar Products]
NCBI Protein Information
BTB/POZ domain-containing protein KCTD11
UniProt Protein Name
BTB/POZ domain-containing protein KCTD11
UniProt Synonym Gene Names
UniProt Entry Name
KCD11_HUMAN
UniProt Comments for KCTD11
KCTD11: Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Acts as an E3 ubiquitin-protein ligase towards HDAC1, leading to its proteasomal degradation. Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcrition factor GLI1, thus maintaining cerebellar granule cells in undifferentiated state, this effect probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. When knock- down, Hedgehog antagonism is impaired and proliferation of granule cells is sustained. Activates the caspase cascade. 2 isoforms of the human protein are produced by alternative initiation.
Protein type: Tumor suppressor
Chromosomal Location of Human Ortholog: 17p13.1
Cellular Component: cytoplasm
Biological Process: cell cycle; negative regulation of neuroblast proliferation; negative regulation of smoothened signaling pathway; positive regulation of neuron differentiation; protein homooligomerization; protein ubiquitination; regulation of growth
Research Articles on KCTD11
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Diseases associated with KCTD11 blocking peptide
Organs/Tissues associated with KCTD11 blocking peptide
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