NP_076173.1
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NCBI GenBank Nucleotide #
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UniProt Related Accession #
Molecular Weight
29,551 Da
NCBI Official Full Name
lck-interacting transmembrane adapter 1
NCBI Official Synonym Full Names
Lck interacting transmembrane adaptor 1
NCBI Protein Information
lck-interacting transmembrane adapter 1
UniProt Protein Name
Lck-interacting transmembrane adapter 1
UniProt Synonym Protein Names
Lck-interacting molecule
UniProt Synonym Gene Names
UniProt Entry Name
LIME1_MOUSE
UniProt Comments for Lime1
LIME1: Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and TCR (T-cell antigen receptor)-mediated T- cell signaling in T-cells. In absence of TCR signaling, may be involved in CD4-mediated inhibition of T-cell activation. Couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization or MAPK activation through the recruitment of PLCG2, GRB2, GRAP2, and other signaling molecules. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Adaptor/scaffold; Membrane protein, integral
Cellular Component: B cell receptor complex; extracellular space; integral to membrane; membrane; plasma membrane
Molecular Function: protein binding; protein kinase binding
Biological Process: adaptive immune response; B cell receptor signaling pathway; immune system process; regulation of I-kappaB kinase/NF-kappaB cascade; regulation of MAP kinase activity; regulation of NF-kappaB import into nucleus; regulation of phosphoinositide 3-kinase cascade; regulation of release of sequestered calcium ion into cytosol; regulation of transcription from RNA polymerase II promoter; T cell receptor signaling pathway
Research Articles on Lime1
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Pathways associated with Lime1 blocking peptide
Organs/Tissues associated with Lime1 blocking peptide
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