NP_006167.1
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NCBI GenBank Nucleotide #
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UniProt Related Accession #
Molecular Weight
7,618 Da
NCBI Official Full Name
neurogranin
NCBI Official Synonym Full Names
neurogranin
NCBI Official Synonym Symbols
NCBI Protein Information
neurogranin
UniProt Protein Name
Neurogranin
UniProt Synonym Protein Names
RC3
UniProt Synonym Gene Names
UniProt Entry Name
NEUG_HUMAN
NCBI Summary for NRGN
Neurogranin (NRGN) is the human homolog of the neuron-specific rat RC3/neurogranin gene. This gene encodes a postsynaptic protein kinase substrate that binds calmodulin in the absence of calcium. The NRGN gene contains four exons and three introns. The exons 1 and 2 encode the protein and exons 3 and 4 contain untranslated sequences. It is suggested that the NRGN is a direct target for thyroid hormone in human brain, and that control of expression of this gene could underlay many of the consequences of hypothyroidism on mental states during development as well as in adult subjects. [provided by RefSeq, Jul 2008]
UniProt Comments for NRGN
neurogranin: Acts as a third messenger substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium. Belongs to the neurogranin family.
Protein type: Cell development/differentiation
Chromosomal Location of Human Ortholog: 11q24
Cellular Component: axon; cell soma; mitochondrial membrane; nucleus; postsynaptic density; trans-Golgi network transport vesicle membrane
Molecular Function: calmodulin binding; phosphatidylinositol-3,4,5-triphosphate binding
Biological Process: associative learning; nervous system development; signal transduction; telencephalon development
Research Articles on NRGN
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Diseases associated with NRGN blocking peptide
Organs/Tissues associated with NRGN blocking peptide
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