NP_067013.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
38,336 Da
NCBI Official Full Name
polypyrimidine tract-binding protein 2 isoform 6
NCBI Official Synonym Full Names
polypyrimidine tract binding protein 2
NCBI Protein Information
polypyrimidine tract-binding protein 2
UniProt Protein Name
Polypyrimidine tract-binding protein 2
UniProt Synonym Protein Names
Neural polypyrimidine tract-binding protein; Neurally-enriched homolog of PTB; PTB-like protein
UniProt Synonym Gene Names
UniProt Entry Name
PTBP2_HUMAN
NCBI Summary for PTBP2
The protein encoded by this gene binds to intronic polypyrimidine clusters in pre-mRNA molecules and is implicated in controlling the assembly of other splicing-regulatory proteins. This protein is very similar to the polypyrimidine tract binding protein (PTB) but most of its isoforms are expressed primarily in the brain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
UniProt Comments for PTBP2
PTBP2: RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. Beside its function in pre- mRNA splicing, plays also a role in the regulation of translation. Isoform 5 has a reduced affinity for RNA. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: RNA-binding; RNA processing
Chromosomal Location of Human Ortholog: 1p21.3
Cellular Component: cell soma; growth cone; spliceosome
Molecular Function: mRNA binding; nucleotide binding
Biological Process: cerebellum development; mRNA splice site selection; negative regulation of RNA splicing; spinal cord development
Research Articles on PTBP2
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Products associated with PTBP2 blocking peptide
Pathways associated with PTBP2 blocking peptide
Diseases associated with PTBP2 blocking peptide
Organs/Tissues associated with PTBP2 blocking peptide
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