NP_002863.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
21,429 Da
NCBI Official Full Name
ras-related C3 botulinum toxin substrate 2
NCBI Official Synonym Full Names
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
NCBI Protein Information
ras-related C3 botulinum toxin substrate 2
UniProt Protein Name
Ras-related C3 botulinum toxin substrate 2
UniProt Synonym Protein Names
GX; Small G protein; p21-Rac2
UniProt Entry Name
RAC2_HUMAN
NCBI Summary for RAC2
This gene encodes a member of the Ras superfamily of small guanosine triphosphate (GTP)-metabolizing proteins. The encoded protein localizes to the plasma membrane, where it regulates diverse processes, such as secretion, phagocytosis, and cell polarization. Activity of this protein is also involved in the generation of reactive oxygen species. Mutations in this gene are associated with neutrophil immunodeficiency syndrome. There is a pseudogene for this gene on chromosome 6. [provided by RefSeq, Jul 2013]
UniProt Comments for RAC2
RAC2: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase. Interacts with DOCK2, which may activate it. Hematopoietic specific. Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase. Belongs to the small GTPase superfamily. Rho family.
Protein type: Motility/polarity/chemotaxis; G protein, monomeric; G protein, monomeric, Rho; G protein
Chromosomal Location of Human Ortholog: 22q13.1
Cellular Component: actin filament; cytosol; focal adhesion; lamellipodium; nuclear envelope; phagocytic vesicle membrane; plasma membrane
Molecular Function: GTP binding; GTPase activity; protein kinase regulator activity
Biological Process: actin filament organization; bone resorption; cell projection biogenesis; chemotaxis; G-protein coupled receptor protein signaling pathway; intracellular protein transport; metabolic process; nucleocytoplasmic transport; platelet activation; positive regulation of cell proliferation; regulation of hydrogen peroxide metabolic process; regulation of mast cell degranulation; regulation of protein kinase activity; regulation of small GTPase mediated signal transduction; regulation of T cell proliferation; signal transduction; small GTPase mediated signal transduction
Disease: Neutrophil Immunodeficiency Syndrome
Research Articles on RAC2
Precautions
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Products associated with RAC2 blocking peptide
Pathways associated with RAC2 blocking peptide
Diseases associated with RAC2 blocking peptide
Organs/Tissues associated with RAC2 blocking peptide
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