NP_002873.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
23,239 Da
NCBI Official Full Name
ran-specific GTPase-activating protein isoform 2
NCBI Official Synonym Full Names
RAN binding protein 1
NCBI Official Synonym Symbols
NCBI Protein Information
ran-specific GTPase-activating protein
UniProt Protein Name
Ran-specific GTPase-activating protein
UniProt Synonym Protein Names
Ran-binding protein 1; RanBP1
UniProt Synonym Gene Names
UniProt Entry Name
RANG_HUMAN
NCBI Summary for RANBP1
This gene encodes a protein that forms a complex with Ras-related nuclear protein (Ran) and metabolizes guanoside triphosphate (GTP). This complex participates in the regulation of the cell cycle by controlling transport of proteins and nucleic acids into the nucleus. There are multiple pseudogenes for this gene on chromosomes 9, 12, 17, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
UniProt Comments for RANBP1
RANBP1: a Ran-binding protein that functions in nuclear trafficking, mitosis, chromosomal segregation, and ciliogenesis. Controls both nuclear import and export. Contains a Ran binding domain and a C-terminal nuclear export signal. Following export from the nucleus, forms a complex with RanGTP and XPO1/cargo, leading to dissociation of cargo from XPO1. Stimulates RanGAP1 association with RanGTP, facilitating RanGTP hydrolysis to RanGDP. Stabilizes and regulates the formation of a RanGDP-importin/NLS receptor-RanBP1 complex during nuclear import. Controls RanGTP distribution along mitotic microtubules, which localizes critical factors, such as cyclin B1 and DLG7, to mitotic microtubles and regulates chromosome segregation. Knock down or overexpression experiments affect cellular ciliogenesis by regulating the local RanGTP concentation at the base of cilia.Belongs to the RANBP1 family.
Protein type: Microtubule-binding; Cell cycle regulation; G protein regulator, misc.
Chromosomal Location of Human Ortholog: 22q11.21
Cellular Component: centrosome; cytoplasm; nuclear envelope; nucleus
Molecular Function: GDP-dissociation inhibitor activity; GTPase activator activity; Ran GTPase binding
Biological Process: G1/S transition of mitotic cell cycle; positive regulation of GTPase activity; positive regulation of mitotic centrosome separation; protein import into nucleus; regulation of catalytic activity; RNA export from nucleus; signal transduction; spindle organization and biogenesis; ubiquitin-dependent protein catabolic process; viral reproduction
Research Articles on RANBP1
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Products associated with RANBP1 blocking peptide
Pathways associated with RANBP1 blocking peptide
Diseases associated with RANBP1 blocking peptide
Organs/Tissues associated with RANBP1 blocking peptide
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