NP_006382.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
119,517 Da
NCBI Official Full Name
importin-7
NCBI Official Synonym Full Names
importin 7
NCBI Official Synonym Symbols
NCBI Protein Information
importin-7
UniProt Protein Name
Importin-7
UniProt Synonym Protein Names
Ran-binding protein 7; RanBP7
UniProt Synonym Gene Names
UniProt Entry Name
IPO7_HUMAN
NCBI Summary for IPO7
The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. Similar to importin-beta, this protein prevents the activation of Ran's GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP, and also binds directly to nuclear pore complexes where it competes for binding sites with importin-beta and transportin. This protein has a Ran-dependent transport cycle and it can cross the nuclear envelope rapidly and in both directions. At least four importin beta-like transport receptors, namely importin beta itself, transportin, RanBP5 and RanBP7, directly bind and import ribosomal proteins. [provided by RefSeq, Jul 2008]
UniProt Comments for IPO7
IPO7: a beta importin protein. Functions in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin beta-1 subunit. A receptor for nuclear localization signals (NLS) that promotes translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran.
Protein type: Nuclear import; Karyopherin; Nuclear export
Chromosomal Location of Human Ortholog: 11p15.4
Cellular Component: cytoplasm; cytosol; membrane; nuclear pore; nucleoplasm
Molecular Function: GTPase regulator activity; histone binding; protein binding; protein transporter activity; Ran GTPase binding; transporter activity
Biological Process: innate immune response; protein import into nucleus; regulation of catalytic activity; signal transduction; viral reproduction
Research Articles on IPO7
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Products associated with IPO7 blocking peptide
Diseases associated with IPO7 blocking peptide
Organs/Tissues associated with IPO7 blocking peptide
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