NP_061830.3
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
50,820 Da
NCBI Official Full Name
SH3 domain-binding protein 1
NCBI Official Synonym Full Names
SH3 domain binding protein 1
NCBI Official Synonym Symbols
NCBI Protein Information
SH3 domain-binding protein 1
UniProt Protein Name
SH3 domain-binding protein 1
UniProt Synonym Gene Names
UniProt Entry Name
3BP1_HUMAN
UniProt Comments for SH3BP1
SH3BP1: Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. This protein binds preferentially to the ABL1 proto-oncogene, SRC and GRB2. Shows GAP activity for Rac-related proteins but not for Rho- or Ras-related proteins. It inhibits PDGF-induced membrane ruffling mediated by Rac. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: GAPs, Rac/Rho; GAPs; Adaptor/scaffold
Chromosomal Location of Human Ortholog: 22q13.1
Cellular Component: cytoplasm
Molecular Function: GTPase activator activity; protein binding; SH3 domain binding
Biological Process: positive regulation of GTPase activity; signal transduction
Research Articles on SH3BP1
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Diseases associated with SH3BP1 blocking peptide
Organs/Tissues associated with SH3BP1 blocking peptide
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