NP_004771.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
18,641 Da
NCBI Official Full Name
transcription elongation factor A protein-like 1
NCBI Official Synonym Full Names
transcription elongation factor A like 1
NCBI Protein Information
transcription elongation factor A protein-like 1
UniProt Protein Name
Transcription elongation factor A protein-like 1
UniProt Synonym Protein Names
Nuclear phosphoprotein p21/SIIR; Transcription elongation factor S-II protein-like 1
UniProt Synonym Gene Names
UniProt Entry Name
TCAL1_HUMAN
NCBI Summary for TCEAL1
This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of this family may function as nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. The encoded protein is similar to transcription elongation factor A/transcription factor SII and contains a zinc finger-like motif as well as a sequence related to the transcription factor SII Pol II-binding region. It may exert its effects via protein-protein interactions with other transcriptional regulators rather than via direct binding of DNA. Multiple family members are located on the X chromosome. Alternative splicing results in multiple transcript variants encoding a single isoform. [provided by RefSeq, Jul 2008]
UniProt Comments for TCEAL1
SIIR: May be involved in transcriptional regulation. Modulates various viral and cellular promoters in a promoter context- dependent manner. For example, transcription from the FOS promoter is increased, while Rous sarcoma virus (RSV) long terminal repeat (LTR) promoter activity is repressed. Does not bind DNA directly. Belongs to the TFS-II family. TFA subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription initiation complex
Chromosomal Location of Human Ortholog: Xq22.1
Cellular Component: nucleoplasm; nucleus
Molecular Function: WW domain binding
Biological Process: negative regulation of transcription from RNA polymerase II promoter
Research Articles on TCEAL1
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Diseases associated with TCEAL1 blocking peptide
Organs/Tissues associated with TCEAL1 blocking peptide
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