NP_003321.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
50,873 Da
NCBI Official Full Name
thioredoxin reductase 1
NCBI Official Synonym Full Names
thioredoxin reductase 1
NCBI Protein Information
thioredoxin reductase 1, cytoplasmic
UniProt Protein Name
Thioredoxin reductase 1, cytoplasmic
UniProt Synonym Protein Names
Gene associated with retinoic and interferon-induced mortality 12 protein; GRIM-12; Gene associated with retinoic and IFN-induced mortality 12 protein; KM-102-derived reductase-like factor; Thioredoxin reductase TR1
UniProt Synonym Gene Names
GRIM12; KDRF; TR; GRIM-12; Gene associated with retinoic and IFN-induced mortality 12 protein [Similar Products]
UniProt Entry Name
TRXR1_HUMAN
NCBI Summary for TXNRD1
This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms. [provided by RefSeq, Jul 2008]
UniProt Comments for TXNRD1
TRXR1: a cytoplasmic pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine residue which is required for the catalytic activity.
Protein type: Nucleotide Metabolism - pyrimidine; Nuclear receptor co-regulator; Oxidoreductase; EC 1.8.1.9
Chromosomal Location of Human Ortholog: 12q23-q24.1
Cellular Component: cytosol; mitochondrion; nucleus
Molecular Function: electron carrier activity; FAD binding; protein binding; protein disulfide oxidoreductase activity; thioredoxin-disulfide reductase activity
Biological Process: cell proliferation; cell redox homeostasis; mesoderm formation; nucleobase, nucleoside and nucleotide interconversion; response to reactive oxygen species; selenium metabolic process; signal transduction
Research Articles on TXNRD1
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Products associated with TXNRD1 blocking peptide
Pathways associated with TXNRD1 blocking peptide
Diseases associated with TXNRD1 blocking peptide
Organs/Tissues associated with TXNRD1 blocking peptide
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