NP_003237.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
thrombospondin-1
NCBI Official Synonym Full Names
thrombospondin 1
NCBI Protein Information
thrombospondin-1; thrombospondin-1p180
UniProt Protein Name
Thrombospondin-1
UniProt Synonym Gene Names
UniProt Entry Name
TSP1_HUMAN
NCBI Summary for THBS1
The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis. [provided by RefSeq, Jul 2008]
UniProt Comments for THBS1
Function: Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp
By similarity. Ligand for CD36 mediating antiangiogenic properties. Ref.12 Ref.20
Subunit structure: Homotrimer; disulfide-linked. Interacts (via the TSP type I repeats) with HRG; the interaction blocks the antiangiogenic effect of THBS1 with CD36
By similarity. Can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1, alpha-V/beta-3 and alpha-IIb/beta-3. Interacts (via the TSP type I repeats) with CD36; the interaction conveys an antiangiogenic effect. Ref.10 Ref.12 Ref.13 Ref.19 Ref.20 Ref.21
Sequence similarities: Belongs to the thrombospondin family.Contains 2 EGF-like domains.Contains 1 laminin G-like domain.Contains 1 TSP C-terminal (TSPC) domain.Contains 3 TSP type-1 domains.Contains 8 TSP type-3 repeats.Contains 1 VWFC domain.
Research Articles on THBS1
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Products associated with THBS1 peptide
Pathways associated with THBS1 peptide
Diseases associated with THBS1 peptide
Organs/Tissues associated with THBS1 peptide
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