NP_787062.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
39,044 Da
NCBI Official Full Name
serine/threonine-protein kinase Kist isoform 1
NCBI Official Synonym Full Names
U2AF homology motif (UHM) kinase 1
NCBI Protein Information
serine/threonine-protein kinase Kist
UniProt Protein Name
Serine/threonine-protein kinase Kist
UniProt Synonym Protein Names
Kinase interacting with stathmin; PAM COOH-terminal interactor protein 2; P-CIP2; U2AF homology motif kinase 1
UniProt Synonym Gene Names
UniProt Entry Name
UHMK1_HUMAN
NCBI Summary for UHMK1
The gene encodes a serine/threonine protein kinase that promotes cell cycle progression through G1 by phosphorylation of the cyclin-dependent kinase inhibitor 1B (p27Kip1), which causes nuclear export and degradation. The encoded protein is also thought to function in the adult nervous system and the gene has been associated with schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
UniProt Comments for UHMK1
KIS: a unique kinase that possesses an RNP type RNA-recognition motif (RRM). A proline-directed kinase with a specificity different from the MAP kinases and CDKs. May be involved in trafficking and/or processing of RNA.
Protein type: EC 2.7.11.1; Protein kinase, Other; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Other group; Other-Unique family
Chromosomal Location of Human Ortholog: 1q23.3
Cellular Component: axon; dendrite cytoplasm; nucleus
Molecular Function: ATP binding; mRNA binding; protein binding; protein serine/threonine kinase activity; ribonucleoprotein binding; transferase activity
Biological Process: cell cycle arrest; mRNA catabolic process, nonsense-mediated decay; neurite development; peptidyl-serine phosphorylation; positive regulation of translational initiation; protein amino acid autophosphorylation; regulation of alternative nuclear mRNA splicing, via spliceosome; regulation of protein export from nucleus
Research Articles on UHMK1
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Products associated with UHMK1 blocking peptide
Diseases associated with UHMK1 blocking peptide
Disease Name |
Pubmed Publications |
Male Urogenital Diseases Antibodies |
>2 publications with UHMK1 and Male Urogenital Diseases |
Neoplasms, Experimental Antibodies |
>1 publications with UHMK1 and Neoplasms, Experimental |
Infertility, Female Antibodies |
>1 publications with UHMK1 and Infertility, Female |
Infertility, Male Antibodies |
>1 publications with UHMK1 and Infertility, Male |
Carcinoma, Hepatocellular Antibodies |
>1 publications with UHMK1 and Carcinoma, Hepatocellular |
Liver Neoplasms, Experimental Antibodies |
>1 publications with UHMK1 and Liver Neoplasms, Experimental |
Liver Diseases Antibodies |
>1 publications with UHMK1 and Liver Diseases |
Cell Transformation, Neoplastic Antibodies |
>1 publications with UHMK1 and Cell Transformation, Neoplastic |
Learning Disorders Antibodies |
>1 publications with UHMK1 and Learning Disorders |
Neoplasm Metastasis Antibodies |
>1 publications with UHMK1 and Neoplasm Metastasis |
Organs/Tissues associated with UHMK1 blocking peptide
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