AAC51155.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
glutamate pyruvate transaminase
NCBI Official Synonym Full Names
glutamic-pyruvate transaminase (alanine aminotransferase)
NCBI Protein Information
alanine aminotransferase 1; GPT 1; glutamic-alanine transaminase 1; glutamic--alanine transaminase 1; glutamic--pyruvic transaminase 1; glutamate pyruvate transaminase 1
UniProt Protein Name
Alanine aminotransferase 2
UniProt Synonym Protein Names
Glutamate pyruvate transaminase 2; GPT 2; Glutamic--alanine transaminase 2; Glutamic--pyruvic transaminase 2
UniProt Synonym Gene Names
UniProt Entry Name
ALAT2_HUMAN
NCBI Summary for GPT
This gene encodes cytosolic alanine aminotransaminase 1 (ALT1); also known as glutamate-pyruvate transaminase 1. This enzyme catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate and, therefore, plays a key role in the intermediary metabolism of glucose and amino acids. Serum activity levels of this enzyme are routinely used as a biomarker of liver injury caused by drug toxicity, infection, alcohol, and steatosis. A related gene on chromosome 16 encodes a putative mitochondrial alanine aminotransaminase.[provided by RefSeq, Nov 2009]
UniProt Comments for GPT
GPT2: Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 2.6.1.2; Transferase; Amino Acid Metabolism - alanine, aspartate and glutamate; Mitochondrial
Chromosomal Location of Human Ortholog: 16q12.1
Cellular Component: mitochondrial matrix
Molecular Function: alanine transaminase activity; pyridoxal phosphate binding
Biological Process: amino acid biosynthetic process; L-alanine metabolic process; 2-oxoglutarate metabolic process; L-alanine catabolic process
Disease: Mental Retardation, Autosomal Recessive 49
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Products associated with GPT active protein
Diseases associated with GPT active protein
Organs/Tissues associated with GPT active protein
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