NP_049501.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
23.8 kDa
NCBI Official Full Name
Shiga toxin 2 subunit B
NCBI Protein Information
Shiga toxin 2 subunit B
UniProt Protein Name
Shiga-like toxin 2 subunit B
UniProt Synonym Protein Names
Verocytotoxin 2 subunit B; Verotoxin 2 subunit B
UniProt Synonym Gene Names
stx2B; SLT-2 B subunit; SLT-2b; SLT-IIb; Verotoxin 2 subunit B [Similar Products]
UniProt Entry Name
STXB_BP933
UniProt Comments for stxB2
The B subunit is responsible for the binding of the holotoxin to specific receptors on the target cell surface, such as globotriaosylceramide (Gb3) in human intestinal microvilli.
Product References and Citations for stxB2 recombinant protein
Nucleotide sequence analysis and comparison of the structural genes for Shiga-like toxin I and Shiga-like toxin II encoded by bacteriophages from Escherichia coli 933.Jackson M.P., Neill R.J., O'Brien A.D., Holmes R.K., Newland J.W.FEMS Microbiol. Lett. 44:109-114(1987)
An ileX tRNA gene is located close to the Shiga toxin II operon in enterohemorrhagic Escherichia coli O157 and non-O157 strains.Schmidt H., Scheef J., Janetzki-Mittmann C., Datz M., Karch H.FEMS Microbiol. Lett. 149:39-44(1997)
Sequence of Shiga toxin 2 phage 933W from Escherichia coli O157:H7
Shiga toxin as a phage late-gene product.Plunkett G. III, Rose D.J., Durfee T.J., Blattner F.R.J. Bacteriol. 181:1767-1778(1999)
Identification of three amino acid residues in the B subunit of Shiga toxin and Shiga-like toxin type II that are essential for holotoxin activity.Perera L.P., Samuel J.E., Holmes R.K., O'Brien A.D.J. Bacteriol. 173:1151-1160(1991)
Structure of shiga toxin type 2 (Stx2)
from Escherichia coli O157:H7.Fraser M.E., Fujinaga M., Cherney M.M., Melton-Celsa A.R., Twiddy E.M., O'Brien A.D., James M.N.G.J. Biol. Chem. 279:27511-27517(2004)
Binding of adenine to Stx2, the protein toxin from Escherichia coli O157:H7.Fraser M.E., Cherney M.M., Marcato P., Mulvey G.L., Armstrong G.D., James M.N.Acta Crystallogr. F 62:627-630(2006)
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