NP_000013
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
42.9 kDa (383aa), confirmed by MALDI-TOF
NCBI Official Full Name
adenosine deaminase isoform 1
NCBI Official Synonym Full Names
adenosine deaminase
NCBI Protein Information
adenosine deaminase
UniProt Protein Name
Adenosine deaminase
UniProt Synonym Protein Names
Adenosine aminohydrolase
UniProt Synonym Gene Names
NCBI Summary for ADA
This gene encodes an enzyme that catalyzes the hydrolysis of adenosine to inosine. Various mutations have been described for this gene and have been linked to human diseases. Deficiency in this enzyme causes a form of severe combined immunodeficiency disease (SCID), in which there is dysfunction of both B and T lymphocytes with impaired cellular immunity and decreased production of immunoglobulins, whereas elevated levels of this enzyme have been associated with congenital hemolytic anemia. [provided by RefSeq, Jul 2008]
UniProt Comments for ADA
Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine (PubMed:8452534, PubMed:16670267). Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4 (PubMed:20959412). Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion (PubMed:11772392). Enhances dendritic cell immunogenicity by affecting dendritic cell costimulatory molecule expression and cytokines and chemokines secretion (). Enhances CD4+ T-cell differentiation and proliferation (PubMed:20959412). Acts as a positive modulator of adenosine receptors ADORA1 and ADORA2A, by enhancing their ligand affinity via conformational change (PubMed:23193172). Stimulates plasminogen activation (PubMed:15016824). Plays a role in male fertility (PubMed:21919946, PubMed:26166670). Plays a protective role in early postimplantation embryonic development ().
Product References and Citations for ADA active protein
Gines S., et al. (2002) Biochem. 361:203-209; Daddona P.E., et al. (1984) J. Biol. Chem. 259:12101-12106
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Products associated with ADA active protein
Pathways associated with ADA active protein
Diseases associated with ADA active protein
Organs/Tissues associated with ADA active protein
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