NP_003151.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Homo sapiens aurora kinase C (AURKC), transcript variant 3, mRNA
NCBI Official Synonym Full Names
aurora kinase C
NCBI Official Synonym Symbols
AIE2; AIK3; ARK3; AurC; SPGF5; STK13; aurora-C [Similar Products]
NCBI Protein Information
aurora kinase C; ARK-3; aurora 3; aurora-related kinase 3; aurora/IPL1/EG2 protein 2; aurora/IPL1-related kinase 3; serine/threonine-protein kinase 13; serine/threonine-protein kinase aurora-C; serine/threonine kinase 13 (aurora/IPL1-like)
UniProt Protein Name
Aurora kinase C
UniProt Synonym Protein Names
Aurora 3; Aurora/IPL1-related kinase 3; ARK-3; Aurora-related kinase 3; Aurora/IPL1/Eg2 protein 2; Serine/threonine-protein kinase 13; Serine/threonine-protein kinase aurora-C
UniProt Synonym Gene Names
UniProt Entry Name
AURKC_HUMAN
NCBI Summary for AURORA C
This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
UniProt Comments for AURORA C
Function: Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'. Ref.4 Ref.8 Ref.9 Ref.10 Ref.12 Ref.13
Catalytic activity: ATP + a protein = ADP + a phosphoprotein.
Enzyme regulation: Okadaic acid, an inhibitor of protein phosphatase 1 (PP1), protein phosphatase 2A (PP2A) and protein phosphatase 5 (PP5), increases AURKC activity. AURKC is also stabilized through its interaction with INCENP, which acts also as an activator. Ref.9
Subunit structure: Component of the chromosomal passenger complex (CPC) composed of at least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB and AURKC. Interacts directly with BIRC5/survivin and INCENP. Interacts with TACC1. Ref.8 Ref.9 Ref.10 Ref.12
Subcellular location: Nucleus. Chromosome. Chromosome › centromere. Cytoplasm › cytoskeleton › spindle. Note: Distributes in the condensed chromosomes during prophase to metaphase. After entering anaphase, there is a dissociation from separated chromosomes and a redistribution to midzone microtubules, and finally remains in the midbody during cytokinesis. Ref.1 Ref.3 Ref.4 Ref.8 Ref.9 Ref.10 Ref.12 Ref.13
Tissue specificity: Isoform 1 and isoform 2 are expressed in testis. Elevated expression levels were seen only in a subset of cancer cell lines such as Hep-G2, Huh-7 and HeLa. Expression is maximum at M phase. Ref.4
Induction: Expression is cell cycle-regulated, with an increase during G2 and M phases. Ref.3 Ref.8 Ref.9
Involvement in disease: Spermatogenic failure 5 (SPGF5) [MIM:243060]: An infertility disorder caused by spermatogenesis defects. Semen from affected men show close to 100% morphologically abnormal multiflagellar spermatozoa with low motility, oversized irregular heads, and abnormal midpiece and acrosome.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.11 Ref.14
Sequence similarities: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.Contains 1 protein kinase domain.
Product References and Citations for AURORA C recombinant protein
1. Steven, L. et al: Targeting Aurora-2 Kinase in Cancer. Molecular Cancer Therapeutics. 2003;2: 589-595. 2. Shingo, T. et al: The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase. Genes to Cells. 2004; 9: 383-397.
Research Articles on AURORA C
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Products associated with AURORA C recombinant protein
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Diseases associated with AURORA C recombinant protein
Organs/Tissues associated with AURORA C recombinant protein
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