P06529.1
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
25.6 kDa
NCBI Official Full Name
Type-2 restriction enzyme BsuRI
NCBI Official Synonym Full Names
inhibin, beta B
NCBI Protein Information
inhibin beta B chain; Inhibin, beta-2; activin beta-B chain; activin AB beta polypeptide
UniProt Protein Name
Type-2 restriction enzyme BsuRI
UniProt Synonym Protein Names
Endonuclease BsuRI; Type II restriction enzyme BsuRI
UniProt Synonym Gene Names
UniProt Entry Name
T2BR_BACIU
NCBI Summary for Activin-B
The inhibin beta B subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta B subunit forms a homodimer, activin B, and also joins with the beta A subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion. [provided by RefSeq, Jul 2008]
UniProt Comments for Activin-B
Function: Recognizes the double-stranded sequence GGCC and cleaves after G-2.
Catalytic activity: Endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates.
Cofactor: Magnesium.
Subunit structure: Monomer.
Research Articles on Activin-B
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Pathways associated with Activin-B active protein
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