NP_001164623.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Predicted Molecular Mass: 44.2kDa Accurate Molecular Mass: 43kDa as determined by SDS-PAGE reducing conditions.
NCBI Official Full Name
annexin A1
NCBI Protein Information
annexin A1; p35; annexin I; annexin-1; calpactin-2; calpactin II; lipocortin I; chromobindin-9; phospholipase A2 inhibitory protein
UniProt Protein Name
Annexin A1
UniProt Synonym Protein Names
Annexin I; Annexin-1; Calpactin II; Calpactin-2; Chromobindin-9; Lipocortin I; Phospholipase A2 inhibitory protein; p35
UniProt Synonym Gene Names
UniProt Entry Name
ANXA1_RABIT
UniProt Comments for ANXA1
Function: Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity.
Subunit structure: Homodimer in placenta (20%); linked by transglutamylation. Interacts with DYSF
By similarity.
Subcellular location: Nucleus. Cytoplasm. Cell projection › cilium. Basolateral cell membrane. Note: Found in the cilium, nucleus and basolateral cell membrane of ciliated cells in the tracheal endothelium. Found in the cytoplasm of type II pneumocytes and alveolar macrophages. Ref.2
Tissue specificity: In the lung, expressed in the ciliated cells of the tracheal endothelium, but not in the goblet cells. Expressed in type II pneumocytes and alveolar macrophages. Ref.2
Domain: A pair of annexin repeats may form one binding site for calcium and phospholipid.
Post-translational modification: Phosphorylated by protein kinase C, epidermal growth factor receptor/kinase and TRPM7. Phosphorylation results in loss of the inhibitory activity
By similarity.
Sequence similarities: Belongs to the annexin family.Contains 4 annexin repeats.
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Products associated with ANXA1 recombinant protein
Diseases associated with ANXA1 recombinant protein
Organs/Tissues associated with ANXA1 recombinant protein
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