P0C736.1
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UniProt Primary Accession #
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NCBI Official Full Name
Apoptosis regulator BHRF1
UniProt Protein Name
Apoptosis regulator BHRF1
UniProt Synonym Protein Names
Early antigen protein R; EA-R; Nuclear antigen
UniProt Synonym Gene Names
UniProt Entry Name
EAR_EBVG
UniProt Comments for EA-R
Function: Prevents premature death of the host cell during virus production, which would otherwise reduce the amount of progeny virus. Acts as a host B-cell leukemia/lymphoma 2 (Bcl-2) homolog, and interacts with pro-apoptotic proteins to prevent mitochondria permeabilization, release of cytochrome c and subsequent apoptosis of the host cell
By similarity.
Subunit structure: Interacts with isoform 1 of host VRK2; this interaction is involved in protecting cells from apoptosis. Interacts with host PRA1; this interaction seems to modulate BHRF1 anti-apoptotic activity. Interacts with host BCL2L11
By similarity.
Subcellular location: Host membrane; Single-pass membrane protein
Potential. Host mitochondrion. Note: also observed in the perinuclear region of the cell
By similarity.
Miscellaneous: EA-R is part of the restricted EA-complex.
Sequence similarities: Belongs to the Bcl-2 family.
Research Articles on EA-R
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Products associated with EA-R recombinant protein
Pathways associated with EA-R recombinant protein
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