NP_062530.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
67.6 kDa
NCBI Official Full Name
beclin-1
NCBI Official Synonym Full Names
beclin 1, autophagy related
NCBI Official Synonym Symbols
Atg6; 4921513J16Rik; 5430417M23Rik [Similar Products]
NCBI Protein Information
beclin-1; Bcl-2-interacting protein beclin; coiled-coil myosin-like BCL2-interacting protein; coiled-coil, myosin-like BCL2-interacting protein
UniProt Protein Name
Beclin-1
UniProt Synonym Protein Names
Coiled-coil myosin-like BCL2-interacting protein
UniProt Entry Name
BECN1_MOUSE
UniProt Comments for Becn1
beclin 1: an essential autophagy protein that has been linked to multiple processes including tumor suppression, protection against some cardiac and neurological degenerative diseases, and lifespan extension. A ubiquitous protein of the beclin family. Is part of the class III PI3K complex that induces autophagy. Expressed at elevated levels in dendrites and cell bodies of cerebellar Purkinje cells. Interacts with the anti-apoptotic protein Bcl-2, which inhibits autophagy when it is present in the endoplasmic reticulum. The dissociation of ATG6 from Bcl-2 is essential for its autophagic activity. Interacts with PITC and GluR-delta2. Probably forms a complex with AMBRA1 and PIK3C3. Plays a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus.
Protein type: Adaptor/scaffold; Autophagy; Membrane protein, peripheral
Cellular Component: Golgi apparatus; protein complex; extrinsic to membrane; cytoskeleton; mitochondrion; membrane; endoplasmic reticulum; cytoplasmic membrane-bound vesicle; dendrite; cytoplasm; trans-Golgi network; phagocytic vesicle; nucleus; endosome
Molecular Function: protein binding; phosphoinositide 3-kinase binding
Biological Process: late endosome to vacuole transport; cytokinesis; response to other organism; cell cycle; CVT pathway; cellular response to nitrogen starvation; negative regulation of cell proliferation; cell division; regulation of catalytic activity; lysosome organization and biogenesis; beta-amyloid metabolic process; mitochondrion degradation; neuron development; autophagy; angiogenesis; defense response to virus; positive regulation of macroautophagy; positive regulation of autophagy; negative regulation of apoptosis; autophagic vacuole formation
Research Articles on Becn1
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Products associated with Becn1 recombinant protein
Pathways associated with Becn1 recombinant protein
Diseases associated with Becn1 recombinant protein
Organs/Tissues associated with Becn1 recombinant protein
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