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Add To Compare List CASP3 recombinant protein :: Caspase-3 (CASP3) Recombinant Protein Catalog # MBS1399898 Unit / Price 0.02 mg (E-Coli) / $660 +1 FREE 8GB USB 0.1 mg (E-Coli) / $770 +1 FREE 8GB USB 0.02 mg (Yeast) / $830 +1 FREE 8GB USB 0.1 mg (Yeast) / $970 +1 FREE 8GB USB 0.02 mg (Baculovirus) / $1,075 +1 FREE 8GB USB 0.02 mg (Mammalian-Cell) / $1,310 +1 FREE 8GB USB 1 mg (E-Coli) / $1,355 +1 FREE 8GB USB 0.1 mg (Baculovirus) / $1,490 +1 FREE 8GB USB 1 mg (Yeast) / $1,890 +2 FREE 8GB USB 0.1 mg (Mammalian-Cell) / $2,120 +2 FREE 8GB USB 1 mg (Baculovirus) / $2,940 +3 FREE 8GB USB 0.5 mg (Mammalian-Cell) / $5,760 +7 FREE 8GB USB Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name Caspase-3 (CASP3), Recombinant Protein Full Product Name Recombinant Bovine Caspase-3 (CASP3) Product Gene Name CASP3 recombinant protein[Similar Products] Product Synonym Gene Name CASP3[Similar Products] Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP Sequence Positions 29-175, full length protein Sequence SGISLEESYK MDYPEMGLCI IINNKNFHEN TGMACRSGTD VDAANLRETF MNLKYEVRIK NDLTCKEMLE LMSNVSKEDH SKRSSFICVL LSHGEEGIIF GTNGPVNLKK LASFFRGDYC RSLTGKPKLF IIQACRGTEL DCGIETD 3D Structure ModBase 3D Structure for Q08DY9 Host E Coli or Yeast or Baculovirus or Mammalian Cell Purity/Purification Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific) Form/Format Lyophilized or liquid (Format to be determined during the manufacturing process) Tag Information This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information. Sterility Sterile filter available upon request. Endotoxin Low endotoxin available upon request. Species Bovine Preparation and Storage Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended. ISO Certification Manufactured in an ISO 9001:2015 Certified Laboratory. Other Notes Small volumes of CASP3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Related Product Information for CASP3 recombinant protein This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer s disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. NCBI/Uniprot data below describe general gene information for CASP3. It may not necessarily be applicable to this product. NCBI GI # 118150794 NCBI GeneID 408016 NCBI Accession # NP_001071308.1 [Other Products] NCBI GenBank Nucleotide # NM_001077840.1 [Other Products] UniProt Primary Accession # Q08DY9 [Other Products] UniProt Related Accession # Q08DY9[Other Products] Molecular Weight 31,136 Da TOP NCBI Official Full Name caspase-3 NCBI Official Synonym Full Names caspase 3 NCBI Official Symbol CASP3 [Similar Products] NCBI Protein Information caspase-3 UniProt Protein Name Caspase-3 Protein Family Caspase UniProt Gene Name CASP3 [Similar Products] UniProt Synonym Gene Names CASP-3 [Similar Products] TOP TOP UniProt Comments for CASP3 Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (). Research Articles on CASP3 1. Over-expression of STC-1 up-regulated Bcl-2 protein expression and slightly down-regulated caspase-3 production in the damaged cells. Findings from this study suggest that STC-1 plays a protective role in intestinal cells through an antioxidant mechanism. TOP Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information. TOP Products associated with CASP3 recombinant protein Reference Product PubMed Publications CASP9 recombinant protein >7299 publications with CASP3 and CASP9 CASP8 recombinant protein >5152 publications with CASP3 and CASP8 XIAP recombinant protein >978 publications with CASP3 and XIAP CASP6 recombinant protein >473 publications with CASP3 and CASP6 APAF1 recombinant protein >348 publications with CASP3 and APAF1 CASP2 recombinant protein >57 publications with CASP3 and CASP2 BIRC3 recombinant protein >47 publications with CASP3 and BIRC3 PAK2 recombinant protein >31 publications with CASP3 and PAK2 CDH1 recombinant protein >10 publications with CASP3 and CDH1 DFFA recombinant protein >5 publications with CASP3 and DFFA Pathways associated with CASP3 recombinant protein Products by Pathway Pathway Diagram Alpha6-Beta4 Integrin Signaling Pathway antibodies Alpha6-Beta4 Integrin Signaling Pathway Diagram Alzheimer's Disease Pathway antibodies Alzheimer's Disease Pathway Diagram Alzheimer's Disease Pathway antibodies Alzheimer's Disease Pathway Diagram Amoebiasis Pathway antibodies Amoebiasis Pathway Diagram Amoebiasis Pathway antibodies Amoebiasis Pathway Diagram Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram Androgen Receptor Signaling Pathway antibodies Androgen Receptor Signaling Pathway Diagram Apoptosis Pathway antibodies Apoptosis Pathway Diagram Apoptosis Pathway antibodies Apoptosis Pathway Diagram Diseases associated with CASP3 recombinant protein Disease Name Pubmed Publications Necrosis Antibodies >6413 publications with CASP3 and Necrosis Nervous System Diseases Antibodies >5034 publications with CASP3 and Nervous System Diseases Inflammation Antibodies >3501 publications with CASP3 and Inflammation Reperfusion Injury Antibodies >2247 publications with CASP3 and Reperfusion Injury Liver Diseases Antibodies >2195 publications with CASP3 and Liver Diseases Brain Ischemia Antibodies >1601 publications with CASP3 and Brain Ischemia Heart Diseases Antibodies >1502 publications with CASP3 and Heart Diseases Breast Neoplasms Antibodies >1401 publications with CASP3 and Breast Neoplasms Neoplasms, Experimental Antibodies >1259 publications with CASP3 and Neoplasms, Experimental Kidney Diseases Antibodies >853 publications with CASP3 and Kidney Diseases Organs/Tissues associated with CASP3 recombinant protein Organ/Tissue Name Pubmed Publications Brain Antibodies >7401 publications with CASP3 and Brain Intestine Antibodies >877 publications with CASP3 and Intestine Pancreas Antibodies >737 publications with CASP3 and Pancreas Uterus Antibodies >221 publications with CASP3 and Uterus Pineal Gland Antibodies >38 publications with CASP3 and Pineal Gland Uncharacterized Tissue Antibodies >6 publications with CASP3 and Uncharacterized Tissue Rumen Antibodies >4 publications with CASP3 and Rumen TOP © 2006-24 MyBioSource.com. 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