NP_057427.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
82.2 kDa
NCBI Official Full Name
centromere protein F
NCBI Official Synonym Full Names
centromere protein F
NCBI Official Synonym Symbols
CENF; hcp-1; CILD31; STROMS; PRO1779 [Similar Products]
NCBI Protein Information
centromere protein F
UniProt Protein Name
Centromere protein F
UniProt Synonym Protein Names
AH antigen; Kinetochore protein CENPF; Mitosin
UniProt Synonym Gene Names
NCBI Summary for CENPF
This gene encodes a protein that associates with the centromere-kinetochore complex. The protein is a component of the nuclear matrix during the G2 phase of interphase. In late G2 the protein associates with the kinetochore and maintains this association through early anaphase. It localizes to the spindle midzone and the intracellular bridge in late anaphase and telophase, respectively, and is thought to be subsequently degraded. The localization of this protein suggests that it may play a role in chromosome segregation during mitotis. It is thought to form either a homodimer or heterodimer. Autoantibodies against this protein have been found in patients with cancer or graft versus host disease. [provided by RefSeq, Jul 2008]
UniProt Comments for CENPF
Required for kinetochore function and chromosome segregation in mitosis. Required for kinetochore localization of dynein, LIS1, NDE1 and NDEL1. Regulates recycling of the plasma membrane by acting as a link between recycling vesicles and the microtubule network though its association with STX4 and SNAP25. Acts as a potential inhibitor of pocket protein-mediated cellular processes during development by regulating the activity of RB proteins during cell division and proliferation. May play a regulatory or permissive role in the normal embryonic cardiomyocyte cell cycle and in promoting continued mitosis in transformed, abnormally dividing neonatal cardiomyocytes. Interaction with RB directs embryonic stem cells toward a cardiac lineage. Involved in the regulation of DNA synthesis and hence cell cycle progression, via its C-terminus. Has a potential role regulating skeletal myogenesis and in cell differentiation in embryogenesis. Involved in dendritic cell regulation of T-cell immunity against chlamydia.
Research Articles on CENPF
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Products associated with CENPF recombinant protein
Pathways associated with CENPF recombinant protein
Diseases associated with CENPF recombinant protein
Organs/Tissues associated with CENPF recombinant protein
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