NP_001106987.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
collagen alpha-1(II) chain isoform 2
NCBI Official Synonym Full Names
collagen, type II, alpha 1
NCBI Official Synonym Symbols
Dmm; Lpk; Col2; Del1; Col2a; Col2a-1; M100856; Rgsc856 [Similar Products]
NCBI Protein Information
collagen alpha-1(II) chain; collagen alpha-1(II) chain; chondrocalcin; alpha-1 type II collagen; disproportionate micromelia; procollagen, type II, alpha 1
UniProt Protein Name
Collagen alpha-1(II) chain
UniProt Synonym Protein Names
Alpha-1 type II collagen
UniProt Entry Name
CO2A1_MOUSE
UniProt Comments for COL2a1
COL2A1: the alpha-1 chain of type II collagen, an extra-cellular matrix protein found in cartilage and the vitreous humor of the eye. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces. Chondrocalcin is the calcium binding C-propeptide of this collagen molecule. Defects in this protein are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. There are two transcripts identified for this gene. Belongs to the fibrillar collagen family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted, signal peptide; Secreted; Extracellular matrix
Cellular Component: extracellular matrix; extracellular space; proteinaceous extracellular matrix; collagen; collagen type II; cytoplasm; extracellular region; basement membrane
Molecular Function: identical protein binding; platelet-derived growth factor binding; extracellular matrix structural constituent; metal ion binding
Biological Process: heart morphogenesis; proteoglycan metabolic process; inner ear morphogenesis; collagen fibril organization; palate development; limb morphogenesis; sensory perception of sound; visual perception; regulation of gene expression; skeletal morphogenesis; cartilage development; tissue homeostasis; chondrocyte differentiation; skeletal development; inner ear development; cartilage condensation; endochondral ossification
Research Articles on COL2a1
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Pathways associated with COL2a1 recombinant protein
Diseases associated with COL2a1 recombinant protein
Organs/Tissues associated with COL2a1 recombinant protein
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