NP_872279.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
atrial natriuretic peptide-converting enzyme
NCBI Official Synonym Full Names
corin, serine peptidase
NCBI Protein Information
atrial natriuretic peptide-converting enzyme; pro-ANP-converting enzyme
UniProt Protein Name
Atrial natriuretic peptide-converting enzyme
UniProt Synonym Protein Names
Corin; Pro-ANP-converting enzyme
UniProt Entry Name
CORIN_RAT
UniProt Comments for CRN
Function: Serine-type endopeptidase involved in atrial natriuretic peptide hormone (NPPA) processing. Converts through proteolytic cleavage the non-functional propeptide NPPA into the active hormone, thereby regulating blood pressure in heart and promoting natriuresis, diuresis and vasodilation. Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Also acts as a regulator of sodium reabsorption in kidney. May also process pro-NPPB the B-type natriuretic peptide. Ref.3 Ref.4
Subcellular location: Cell membrane; Single-pass type II membrane protein. Cytoplasmic vesicle Ref.3 Ref.4. Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment: Secreted
By similarity. Note: Soluble form produced following cleavage by ADAM10
By similarity. Ref.3 Ref.4
Tissue specificity: Specifically expressed in heart. Also detected in kidney, aorta, brain and testis. In kidney, present in epithelial cells, with segmental expression in the proximal tubule, thick ascending limb, connecting tubule, and throughout the collecting duct (at protein level). Ref.1
Induction: Down-regulated upon experimental heart failure. Ref.1
Post-translational modification: N-glycosylated; required for processing and activation. Ref.3Activated through proteolytic processing by a trypsin-like protease; cleaved into a N-terminal propeptide and an activated corin protease fragment. Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment is produced by cleavage by ADAM10. Cleavage by ADAM10 to produce soluble 180 kDa soluble fragment takes place after the transmembrane region and before FZ 1
Probable. Ref.3A disulfide bond links the activated corin protease fragment and the N-terminal propeptide. The disulfide bond also links the activated corin protease fragment with Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment
Probable.
Sequence similarities: Belongs to the peptidase S1 family.Contains 2 FZ (frizzled) domains.Contains 7 LDL-receptor class A domains.Contains 1 peptidase S1 domain.Contains 1 SRCR domain.
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Products associated with CRN recombinant protein
Pathways associated with CRN recombinant protein
Diseases associated with CRN recombinant protein
Organs/Tissues associated with CRN recombinant protein
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