NP_919410
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
43.5 kDa (403aa), confirmed by MALDI-TOF
NCBI Official Full Name
FGFR1 oncogene partner isoform b
NCBI Official Synonym Full Names
FGFR1 oncogene partner
NCBI Official Synonym Symbols
NCBI Protein Information
FGFR1 oncogene partner
UniProt Protein Name
FGFR1 oncogene partner
UniProt Synonym Gene Names
NCBI Summary for FGFR1OP
This gene encodes a largely hydrophilic centrosomal protein that is required for anchoring microtubules to subcellular structures. A t(6;8)(q27;p11) chromosomal translocation, fusing this gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. Alterations in this gene may also be associated with Crohn's disease, Graves' disease, and vitiligo. Alternatively spliced transcript variants that encode different proteins have been identified. [provided by RefSeq, Jul 2013]
UniProt Comments for FGFR1OP
Required for anchoring microtubules to the centrosomes (PubMed:16314388, PubMed:28659385). Required for ciliation (PubMed:28625565, PubMed:28659385).
Product References and Citations for FGFR1OP recombinant protein
Yan X., et al. (2006) Mol. Biol. Cell. 17:634-644; Mikolajka A., et al. (2006) J. Mol. Biol. 359:863-875
Research Articles on FGFR1OP
Precautions
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Products associated with FGFR1OP recombinant protein
Pathways associated with FGFR1OP recombinant protein
Diseases associated with FGFR1OP recombinant protein
Organs/Tissues associated with FGFR1OP recombinant protein
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