NP_061833.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
32,742 Da
NCBI Official Full Name
glycine N-methyltransferase
NCBI Official Synonym Full Names
glycine N-methyltransferase
NCBI Protein Information
glycine N-methyltransferase; HEL-S-182mP; epididymis secretory sperm binding protein Li 182mP
UniProt Protein Name
Glycine N-methyltransferase
UniProt Entry Name
GNMT_HUMAN
NCBI Summary for GNMT
The protein encoded by this gene is an enzyme that catalyzes the conversion of S-adenosyl-L-methionine (along with glycine) to S-adenosyl-L-homocysteine and sarcosine. The encoded protein is found in the cytoplasm and acts as a homotetramer. Defects in this gene are a cause of GNMT deficiency (hypermethioninemia). [provided by RefSeq, Oct 2008]
UniProt Comments for GNMT
GNMT: Catalyzes the methylation of glycine by using S- adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine. Defects in GNMT are the cause of glycine N- methyltransferase deficiency (GNMT deficiency); also known as hypermethioninemia. The only clinical abnormalities in patients with this deficiency are mild hepatomegaly and chronic elevation of serum transaminases. Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family.
Protein type: Amino Acid Metabolism - glycine, serine and threonine; EC 2.1.1.20; Methyltransferase
Chromosomal Location of Human Ortholog: 6p12
Cellular Component: cytoplasm
Molecular Function: protein binding; glycine N-methyltransferase activity; glycine binding; folic acid binding
Biological Process: glycogen metabolic process; methylation; protein modification process; S-adenosylmethionine metabolic process; methionine metabolic process; regulation of gluconeogenesis; one-carbon compound metabolic process; protein homotetramerization
Disease: Glycine N-methyltransferase Deficiency
Research Articles on GNMT
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Pathways associated with GNMT recombinant protein
Diseases associated with GNMT recombinant protein
Organs/Tissues associated with GNMT recombinant protein
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