NP_001244222.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
65.1 kDa
NCBI Official Full Name
heterogeneous nuclear ribonucleoprotein H
NCBI Official Synonym Full Names
heterogeneous nuclear ribonucleoprotein H1 (H)
NCBI Protein Information
heterogeneous nuclear ribonucleoprotein H
UniProt Protein Name
Heterogeneous nuclear ribonucleoprotein H
UniProt Synonym Gene Names
UniProt Entry Name
HNRH1_HUMAN
NCBI Summary for HNRNPH1
This gene encodes a member of a subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA. These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some may shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNA and is very similar to the family member HNRPF. This gene may be associated with hereditary lymphedema type I. Alternatively spliced transcript variants have been described [provided by RefSeq, Mar 2012]
UniProt Comments for HNRNPH1
hnRNP H1: This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG).
Protein type: Spliceosome; RNA splicing; RNA-binding
Chromosomal Location of Human Ortholog: 5q35.3
Cellular Component: cytoplasm; membrane; nucleoplasm; nucleus
Molecular Function: nucleotide binding; poly(U) binding; protein binding; RNA binding
Biological Process: gene expression; nuclear mRNA splicing, via spliceosome; regulation of RNA splicing; RNA processing; RNA splicing
Product References and Citations for HNRNPH1 recombinant protein
Heterogeneous nuclear ribonucleoproteins H, H', and F are members of a ubiquitously expressed subfamily of related but distinct proteins encoded by genes mapping to different chromosomes.Honore B., Rasmussen H.H., Vorum H., Dejgaard K., Liu X., Gromov P., Madsen P., Gesser B., Tommerup N., Celis J.E.J. Biol. Chem. 270:28780-28789(1995)
Research Articles on HNRNPH1
Precautions
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Products associated with HNRNPH1 recombinant protein
Pathways associated with HNRNPH1 recombinant protein
Diseases associated with HNRNPH1 recombinant protein
Organs/Tissues associated with HNRNPH1 recombinant protein
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