NP_001076092.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
17.6 kDa
NCBI Official Full Name
histidine triad nucleotide-binding protein 1
NCBI Official Synonym Symbols
NCBI Protein Information
histidine triad nucleotide-binding protein 1
UniProt Protein Name
Histidine triad nucleotide-binding protein 1
UniProt Synonym Protein Names
Adenosine 5'-monophosphoramidase; P13.7
UniProt Synonym Gene Names
UniProt Comments for HINT1
Functions as enzyme, and as scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1. Modulates p53/TP53 levels and p53/TP53-mediated apoptosis. Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex (). Hydrolyzes purine nucleotide phosphoramidates, including adenosine 5'monophosphoramidate (AMP-NH2), adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'monophosphomorpholidate (GMP-morpholidate). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) and AMP-N-alanine methyl ester. Can also convert adenosine 5'-O-phosphorothioate and guanosine 5'-O-phosphorothioate to the corresponding nucleoside 5'-O-phosphates with concomitant release of hydrogen sulfide.
Research Articles on HINT1
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Products associated with HINT1 recombinant protein
Diseases associated with HINT1 recombinant protein
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