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Add To Compare List Irs1 recombinant protein :: Insulin receptor substrate 1 (Irs1) Recombinant Protein Catalog # MBS948487 Unit / Price 0.02 mg (E-Coli) / $765 +1 FREE 8GB USB 0.1 mg (E-Coli) / $920 +1 FREE 8GB USB 0.02 mg (Yeast) / $925 +1 FREE 8GB USB 0.1 mg (Yeast) / $1,085 +1 FREE 8GB USB 0.02 mg (Baculovirus) / $1,135 +1 FREE 8GB USB 0.02 mg (Mammalian-Cell) / $1,405 +1 FREE 8GB USB 1 mg (E-Coli) / $1,625 +2 FREE 8GB USB 0.1 mg (Baculovirus) / $1,625 +2 FREE 8GB USB 1 mg (Yeast) / $2,120 +2 FREE 8GB USB 0.1 mg (Mammalian-Cell) / $2,210 +2 FREE 8GB USB 1 mg (Baculovirus) / $3,190 +3 FREE 8GB USB 0.5 mg (Mammalian-Cell) / $5,900 +7 FREE 8GB USB Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name Insulin receptor substrate 1 (Irs1), Recombinant Protein Full Product Name Recombinant Rat Insulin receptor substrate 1 (Irs1) , partial Product Gene Name Irs1 recombinant protein[Similar Products] Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP Sequence Positions 12-259aa; partial Sequence DVRKVGYLRK PKSMHKRFFV LRAASEAGGP ARLEYYENEK KWRHKSSAPK RSIPLESCFN INKRADSKNK HLVALYTRDE HFAIAADSEA EQDSWYQALL QLHNRAKAHH DGAGGGCGGS CSGSSGVGEA GEDLSYDTGP GPAFKEVWQV ILKPKGLGQT KNLIGIYRLC LTSKTISFVK LNSEAAAVVL QLMNIRRCGH SENFFFIEVG RSAVTGPGEF WMQVDDSVVA QNMHETILEA MRAMSDEF 3D Structure ModBase 3D Structure for P35570 Host E Coli or Yeast or Baculovirus or Mammalian Cell Purity/Purification Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific) Form/Format Lyophilized or liquid (Format to be determined during the manufacturing process) Tag Information This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information. Sterility Sterile filter available upon request. Endotoxin Low endotoxin available upon request. Species Rat Preparation and Storage Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended. ISO Certification Manufactured in an ISO 9001:2015 Certified Laboratory. Other Notes Small volumes of Irs1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Related Product Information for Irs1 recombinant protein This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. NCBI/Uniprot data below describe general gene information for Irs1. It may not necessarily be applicable to this product. NCBI GI # 6981106 NCBI GeneID 25467 NCBI Accession # NP_037101.1 [Other Products] NCBI GenBank Nucleotide # NM_012969.1 [Other Products] UniProt Primary Accession # P35570 [Other Products] UniProt Related Accession # P35570[Other Products] Molecular Weight 131,178 Da TOP NCBI Official Full Name insulin receptor substrate 1 NCBI Official Synonym Full Names insulin receptor substrate 1 NCBI Official Symbol Irs1 [Similar Products] NCBI Official Synonym Symbols IRS1IRM [Similar Products] NCBI Protein Information insulin receptor substrate 1 UniProt Protein Name Insulin receptor substrate 1 UniProt Synonym Protein Names pp185 Protein Family Isoleucine--tRNA ligase UniProt Gene Name Irs1 [Similar Products] UniProt Synonym Gene Names Irs-1; IRS-1 [Similar Products] TOP NCBI Summary for Irs1 a docking protein; may act to link the insulin receptor kinase with enzymes regulating cellular growth and metabolism [RGD, Feb 2006] TOP UniProt Comments for Irs1 May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit. Research Articles on Irs1 1. This study determined if dietary restriction (DR) protects against hypoxic-ischemia (HI) in the neonatal brain via insulin receptor substrate-1 (IRS-1)/Akt pathway-mediated downregulation of p53 in the neurovascular unit. TOP Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information. TOP Products associated with Irs1 recombinant protein Reference Product PubMed Publications Igf1r recombinant protein >240 publications with Irs1 and Igf1r Mtor recombinant protein >139 publications with Irs1 and Mtor Grb2 recombinant protein >138 publications with Irs1 and Grb2 Jak2 recombinant protein >62 publications with Irs1 and Jak2 Insr recombinant protein >52 publications with Irs1 and Insr Socs3 recombinant protein >40 publications with Irs1 and Socs3 Ptpn1 recombinant protein >30 publications with Irs1 and Ptpn1 Crk recombinant protein >12 publications with Irs1 and Crk Pik3r1 recombinant protein >12 publications with Irs1 and Pik3r1 Pik3r2 recombinant protein >1 publications with Irs1 and Pik3r2 Pathways associated with Irs1 recombinant protein Products by Pathway Pathway Diagram AMPK Signaling Pathway antibodies AMPK Signaling Pathway Diagram AMPK Signaling Pathway antibodies AMPK Signaling Pathway Diagram Adipocytokine Signaling Pathway antibodies Adipocytokine Signaling Pathway Diagram Adipocytokine Signaling Pathway antibodies Adipocytokine Signaling Pathway Diagram Adipogenesis Pathway antibodies Adipogenesis Pathway Diagram Aldosterone-regulated Sodium Reabsorption Pathway antibodies Aldosterone-regulated Sodium Reabsorption Pathway Diagram Aldosterone-regulated Sodium Reabsorption Pathway antibodies Aldosterone-regulated Sodium Reabsorption Pathway Diagram Alpha6-Beta4 Integrin Signaling Pathway antibodies Alpha6-Beta4 Integrin Signaling Pathway Diagram EPO Receptor Signaling Pathway antibodies EPO Receptor Signaling Pathway Diagram FoxO Signaling Pathway antibodies FoxO Signaling Pathway Diagram Diseases associated with Irs1 recombinant protein Disease Name Pubmed Publications Insulin Resistance Antibodies >1219 publications with Irs1 and Insulin Resistance Hyperinsulinism Antibodies >828 publications with Irs1 and Hyperinsulinism Diabetes Mellitus Antibodies >489 publications with Irs1 and Diabetes Mellitus Obesity Antibodies >413 publications with Irs1 and Obesity Diabetes Mellitus, Type 2 Antibodies >334 publications with Irs1 and Diabetes Mellitus, Type 2 Disease Models, Animal Antibodies >199 publications with Irs1 and Disease Models, Animal Hyperglycemia Antibodies >179 publications with Irs1 and Hyperglycemia Necrosis Antibodies >176 publications with Irs1 and Necrosis Liver Diseases Antibodies >134 publications with Irs1 and Liver Diseases Inflammation Antibodies >133 publications with Irs1 and Inflammation Organs/Tissues associated with Irs1 recombinant protein Organ/Tissue Name Pubmed Publications Muscle Antibodies >742 publications with Irs1 and Muscle Liver Antibodies >388 publications with Irs1 and Liver Connective Tissue Antibodies >212 publications with Irs1 and Connective Tissue Pancreas Antibodies >127 publications with Irs1 and Pancreas Ovary Antibodies >99 publications with Irs1 and Ovary Heart Antibodies >94 publications with Irs1 and Heart Brain Antibodies >89 publications with Irs1 and Brain Kidney Antibodies >85 publications with Irs1 and Kidney Nerve Antibodies >40 publications with Irs1 and Nerve Bone Antibodies >34 publications with Irs1 and Bone TOP © 2006-24 MyBioSource.com. 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